Lathrop R. H., Rogers Jr R. G., Smith T. F.'s A Bayes-optimal sequence-structure theory that unifies PDF

By Lathrop R. H., Rogers Jr R. G., Smith T. F.

A rigorous Bayesian research is gifted that unifies protein sequence-structure alignment and popularity. Given a series, specific formulae are derived to choose (1) its globally such a lot possible middle constitution from a constitution library; (2) its globally such a lot possible alignment to a given middle constitution; (3) its such a lot possible joint center constitution and alignment selected globally around the whole library; and (4) its so much possible person segments, secondary constitution, and super-secondary constructions around the complete library. The computations concerned are NP-hard within the normal case (3D-3D). quick designated recursions for the limited series singleton-only (1D-3D) case are given. Conclusions contain: (a) the main possible joint center constitution and alignment isn't unavoidably the main possible alignment of the main possible center constitution, yet relatively maximizes the fabricated from center and alignment percentages; (b) use of a sequence-independent linear or affine hole penalty may end up within the highest-probability threading no longer having the bottom rating; (c) identifying the main possible center constitution from the library (core constitution choice or fold popularity in simple terms) includes evaluating chances summed over all attainable alignments of the series to the center, and never evaluating person optimum (or near-optimal) sequence-structure alignments; and (d) assuming uninformative priors, middle constitution choice is resembling evaluating the ratio of 2 international ability.

Show description

Read or Download A Bayes-optimal sequence-structure theory that unifies protein sequence-structure recognition and alignment PDF

Best biotechnology books

Biotechnology and Ecology of Pollen: Proceedings of the by M. B. Singh, R. B. Knox (auth.), David L. Mulcahy, Gabriella PDF

In reputation of the Forgotten new release D. L. MULCAHyl Pollen was once lengthy believed to serve essentially a unmarried functionality, that of providing male gametes to the egge A secondary and usually ignored price of pollen is that it serves to dam the transmission of many faulty alleles and gene mixtures into the subsequent new release.

Download e-book for iPad: Micro and Nanotechnologies in Engineering Stem Cells and by Murugan Ramalingam, Esmaiel Jabbari, Seeram Ramakrishna, Ali

A state-of-the-art examine the applying of micro and nanotechnologies in regenerative medicineThe sector on the interface of micro/nanotechnology and stem cells/tissue engineering has obvious an explosion of job lately. This e-book offers a much-needed review of those interesting advancements, protecting all features of micro and nanotechnologies, from the basic ideas to the most recent learn to purposes in regenerative medication.

Download e-book for kindle: Biotechnology of Silk by Robert S. Weber, Catherine L. Craig (auth.), Tetsuo Asakura,

This ebook is a image of the present cutting-edge of study and improvement at the houses and features of silk and their use in medication and undefined. the sector encompasses yard silk construction from old time to commercial equipment within the sleek period and comprises an instance of efforts to take care of silk creation on Madagascar.

Get Biotechnology and Food Safety. Proceedings of the Second PDF

The court cases of the second one overseas Symposium on Biotechnology and meals defense which addresses the present functions of biotechnolgy to meals protection. The paintings may be of curiosity to researchers in nutrients, agricultural and plant biotechnology, in addition to crop scientists

Extra info for A Bayes-optimal sequence-structure theory that unifies protein sequence-structure recognition and alignment

Example text

Global optimum protein threading with gapped alignment and empirical pair score functions. J. Mol. Biol. 255, 641-665. Lawrence, C. , S. F. Altschul, M. S. Boguski, J. S. Liu, A. F. Neuwald and J. C. Wootton (1993). Detecting subtle sequence signals: a Gibbs sampling strategy for multiple alignment. Science 262, 208214. Lemer, C. , M. J. Rooman and S. J. Wodak (1995). Protein structure prediction by threading methods: Evaluation of current techniques. Proteins: Structure, Function, and Genetics 23 337-355.

Shamir and M. Waterman (Eds), New York: ACM Press, pp. 285-292. , R. Rosenfeld, S. Vajda and C. DeLisi (1993). Determining protein loop conformation using scaling-relaxation techniques. Protein Sci. 2, 1242- 1248.

Marks (1992). Computational complexity of a problem in molecular structure prediction. Protein Engng 5, 3 13-32 1. , A. A. Rashin and R. E. Bruccoleri (1988). Criteria that discriminate between native proteins and incorrectly folded models. Proteins: Structure, Function, and Genetics 4, 19-30. Orengo, C. , D. T. Jones and J. M. Thornton (1994). Protein superfamilies and domain superfolds. Nature (London) 372, 631-634. , C. Sander, M. Scharf and R. Schneider (1993). Prediction of protein structure by evaluation of sequence-structure fitness.

Download PDF sample

A Bayes-optimal sequence-structure theory that unifies protein sequence-structure recognition and alignment by Lathrop R. H., Rogers Jr R. G., Smith T. F.


by Jeff
4.1

Rated 4.15 of 5 – based on 37 votes