By Emre Akkus MD (auth.), Laurence A. Levine MD, FACS (eds.)
Previously thought of infrequent, Peyronie's ailment impacts approximately 10% of grownup males. contemporary advances in wound-healing issues have considerably elevated the certainty of Peyronie's sickness and its pathophysiology. In Peyronie's sickness: A advisor to scientific administration, foreign experts overview the present nonsurgical and surgical healing thoughts for facing this fibrotic illness. a number of state of the art examine strategies is mentioned, together with tissue research, mobilephone tradition of fibroblasts derived from Peyronie's plaques, and animal versions that try and mimic the in vivo means of tunica albuginea fibrosis whereas additionally supplying a chance for manipulation with novel healing techniques.
Although there isn't any remedy for Peyronie's ailments, this article discusses remedies which could lead to actual development or support to stabilize the scarring procedure. For people with a extra complicated sickness, surgical innovations to right the deformity in order to make the sufferers sensible back are reviewed. additionally mentioned are the various misconceptions approximately Peyronie's affliction, in order that a practising health practitioner can be in a position to diagnose, deal with, or refer the sufferer extra accurately.
As the 1st clinical textual content at the topic, Peyronie's ailment: A consultant to medical administration offers an updated precis of the etiology, typical heritage, and pathophysiology of this illness in addition to provides a evaluation of the to be had scientific and surgical operation suggestions.
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Additional info for Peyronie’S Disease: A Guide to Clinical Management
Eur Urol 2001; 40: 525–530. 17. Shaw K, Puri K, Ruiz-Deya G, Hellstrom WJG. Racial considerations in the evaluation of Peyronie’s disease. J Urol 2001; 165(5), suppl: 170. 18. Williams JL, Thomas GG. The natural history of Peyronie’s disease. J Urol 1970; 103: 75. 19. Kadioglu A, Tefekli A, Erol B, Oktar T, Tunc M, Tellaloglu S. A retrospective review of 307 men with Peyronie’s disease. J Urol 2002; 168: 1075–1079. 20. Lania C, Grasso M, Franzoso F, Blanco S, Rigatti P. Peyronie’s disease, natural history.
Since SOD cDNA has ameliorated erectile dysfunction in the aged rat model (125), these clinical results should encourage the refinement of this approach in the animal models of PD to try to achieve plaque reduction. On the other hand, decorin mRNA has been found consistently increased in human PD and Dupuytren’s nodules (35), suggesting that this is another mechanism of defense against the development of the plaque that may be investigated in the animal models. The use of PAI-1 small interference RNA, which breaks down the mRNA and “silences” gene expression (126), is another avenue to explore based on the findings of a consistent elevation of PAI-1 in both the human PD and the animal PD-like plaque tissues (28,29).
Rhoden EL, Teloken C, Ting HY, Lucas ML, Teodosio da Ros C, Ary Vargas Souto C. Prevalence of Peyronie’s disease in men over 50-yr-old from Southern Brasil. Int J Impot Res 2001; 13: 291–293. 15. Mulhall JP, Creech SD, Boorjian SA, et al. Subjective and objective analysis of the prevalence of Peyronie’s disease in a population of men presenting for prostate cancer. J Urol 2004; 171: 2350–2353. 16. La Pera G, Pescatori ES, Calabrese M, et al. and the Simona Study Group. Peyronie’s disease: prevalence and association with cigarette smoking.
Peyronie’S Disease: A Guide to Clinical Management by Emre Akkus MD (auth.), Laurence A. Levine MD, FACS (eds.)