A Concise Review of Clinical Laboratory Science, 2nd Edition by Joel David Hubbard, Joel Hubbard PDF

By Joel David Hubbard, Joel Hubbard

ISBN-10: 0781782023

ISBN-13: 9780781782029

The second one variation bargains a concise evaluate of all parts of scientific lab technological know-how, together with the normal parts, equivalent to hematology, chemistry, hemostasis, immunohematology, scientific microbiology, parasitology, urinalysis and extra, in addition to lab administration, lab executive laws, and caliber insurance. A significant other web site deals 35 case stories, a picture financial institution of colour photos, and a quiz financial institution with 500 questions in certification layout.

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2) Clearance indicates the number of milliliters of plasma from which the kidney can remove all of a given substance in 1 minute. A request for “clearance” is a request for assessment of glomerular filtration rate. (3) Plasma renal flow is the number of milliliters of plasma passing through the kidney in 1 minute; normal is 625 mL/min. b. Tubular function is to resorb certain substances back into the body. The proximal tubule resorbs 75% of water, sodium, much of glucose, amino acids, certain ions, and small molecules.

17:19 P1: OSO LWBK192-01 LWBK192-Hubbard 20 November 23, 2008 A Concise Review of Clinical Laboratory Science 1. Urea is the major excretory product of protein metabolism and is synthesized in the liver from carbon dioxide and ammonia arising from the deamination of amino acids. It is excreted by the kidney. a. All analytic methods include, in the initial step, the hydrolysis of urea by urease and subsequent production of ammonium. Most techniques are sensitive to excess ammonia contamination. (1) The coupled enzymatic assay is a kinetic assay that involves a second enzyme.

2) The rate of synthesis is controlled through regulation of the enzyme δ-aminolevulinic acid (ALA) synthase by the hemoproteins in the liver. b. Clinical importance (1) Three porphyrin compounds are clinically important: protoporphyrin (excreted in feces), uroporphyrin (excreted in urine), and coproporphyrin (excreted in both). All are intermediate products in the synthesis of heme that can be assessed clinically. (2) Porphobilinogen (PBG) and ALA are precursors of porphyrin and can accumulate in certain porphyrin disorders.

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A Concise Review of Clinical Laboratory Science, 2nd Edition by Joel David Hubbard, Joel Hubbard

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